I'm the CEO of GeneralBiotics.com, we sell a probiotic created using Human Microbiome Project datasets (our CTO did his postdoctoral work there).
The product is not a DIY FMT, but serves a similar function (restore missing aggregate metabolic pathways).
Personally, from generation 1 of our product onwards I've felt considerably less stressed, more upbeat/happy, and haven't had diarrhea (I have IBS-D, so that's a huge one for me personally). Our pilot study has offered us preliminary confirmation of this, so we're paying for a 200 person placebo-controlled follow up study.
Early versions did have hiccups, but IMO gas is FAR preferable to diarrhea.
I don't personally think DIY is worth the risk, as there are a lot of things you'd absolutely need to screen for if you're considering that route (see http://www.medscape.com/viewarticle/776501_4 for a minimal list). I think you should also screen for mental disorders, stress disorders, mood disorders, etc. Basically anything known to be correlated with the microbiome at minimum.
Assuming you've screened for those things (which is to say basically a pro-level FMT), I think it's basically safe -- there are a lot of FMT procedures performed every year with minimal side effects.
#include disclaimer: obviously not medical advice, etc, etc
I've been following the FMT related news recently, and since starting specific probiotics my NSAID related GI issues have been vastly reduced to almost zero pain.
Once you start shipping to Scotland I'll give your product a try!
I signed up and curious how high Canada is on the list... I see a lot of pro/pre biotic products in the store so it is certainly not banned.
Another question... what is your take on the fecal transplant process and do you ever think it could end up in a "pill format"? Are you aware of any such pills in the North American market?
You should add a mailing list to your page. I don't want to order yet, but would be interested in hearing the results of your 200 person study, and potentially ordering in the future.
wow that's super interesting! Align is the only other probiotic I've tried because they actually did some clinical trials with it. I'm ordering some of your product now, gotta support companies that are willing do to actual science, thanks for posting!
Depends on which third party you're using. For product studies, having a University do it runs in the low 100s of thousands, having a CRO do it is mid 10s of thousands to low 100s.
If you're running one that involves disease, doctors, regulators, etc those numbers grow exponentially. FDA trials (which are often less than 200 people) are in the 100s of millions.
Email me (david@generalbiotics.com) if you'd like some help setting one up.
The product is not a DIY FMT, but serves a similar function (restore missing aggregate metabolic pathways).
Personally, from generation 1 of our product onwards I've felt considerably less stressed, more upbeat/happy, and haven't had diarrhea (I have IBS-D, so that's a huge one for me personally). Our pilot study has offered us preliminary confirmation of this, so we're paying for a 200 person placebo-controlled follow up study.
Early versions did have hiccups, but IMO gas is FAR preferable to diarrhea.
I don't personally think DIY is worth the risk, as there are a lot of things you'd absolutely need to screen for if you're considering that route (see http://www.medscape.com/viewarticle/776501_4 for a minimal list). I think you should also screen for mental disorders, stress disorders, mood disorders, etc. Basically anything known to be correlated with the microbiome at minimum.
Assuming you've screened for those things (which is to say basically a pro-level FMT), I think it's basically safe -- there are a lot of FMT procedures performed every year with minimal side effects.
#include disclaimer: obviously not medical advice, etc, etc