In theory, yes. Motion sickness depends on the type of motion. A very bouncy or aggressive ride will result in more sickness, whereas a very smooth ride (such as a train) results in less. It's all about how much confusion there is between what you're seeing and your sense of balance.

As it happens, the same types of driving that are more fuel efficient cause less motion sickness. Still, driving anywhere with stop lights and other traffic probably necessitates enough stopping and starting that even maximally efficient driving software would cause motion sickness in many people.