pypdfium2 is a great choice and a solid piece of software!
You might want to look into https://github.com/VikParuchuri/surya as an alternative to tesseract. Yes, it's associated with a commercial company, but as you long as you aren't a company with 5M in ARR or $5M in funding it's free to use.
this still seems GPL. another OCR worth considering is easyOCR [0] (apache license). AFAIK there is not layout detection but they do provide bounding boxes and support many languages also detecting text on many different world objects from images (signpost, etc)
You might want to look into https://github.com/VikParuchuri/surya as an alternative to tesseract. Yes, it's associated with a commercial company, but as you long as you aren't a company with 5M in ARR or $5M in funding it's free to use.